According to a trial, the 5-alpha reductase inhibitor dutasteride (Avodart) doesn’t influence negatively on muscle mass in healthy men that administer testosterone.
A study connected with this issue was performed. While fat-free mass was increased by 0,6-7,1 kg during 20 weeks in males who applied dutasteride and Testosterone Enanthate, fat-free mass was increased by 0,8-8,1 kg in those that administered placebo and testosterone. As for muscle power, sexual functions and volume of prostate, they didn’t differ in males of these 2 groups.
5-alpha reductase inhibitors are applied clinically to cure benign prostatic hyperplasia (BPH) and androgenic alopecia. These are dysfunctions that commonly occur in middle-aged and elderly men.
DHT represents the chief metabolite of testosterone. But the function of this metabolite in human development is not clearly understood. It is supposed that DHT plays relevant role in development of prostate and phallus.
Middle-aged and elder males with reduced testosterone levels that take testosterone medicines have risks connected with reduced muscle mass and sexual troubles.
Scientists also study and develop nonsteroidal selective androgen receptor modulators (SARMs). It is confirmed that SARMs and 5-alpha reductase inhibitors are safe because DHT is supposedly not necessary for effects on muscle mass, strength and sexual life. It is also doubted whether DHT has any role for androgen’s effects on hematocrit, hemoglobin, lipids and some other factors.
Shalender Bhasin and his colleagues at the Boston University have performed a clinical trial in order to see whether 5?-reduction to DHT is required in order to mediate androgen’s effects on muscle mass. Moreover, the scientist evaluated role of 5?-reduction on sexual activity, hematocrit and levels of lipid.
The study conducted by Bhasin and his colleagues enrolled healthy men who were 18- 50 years old and had normal testosterone levels. They administered Testosterone Enanthate and dutasteride or placebo. Doses of Testosterone Enanthate ranged from 50 to 600 mg per week.
Since 5 ?-reductase inhibitors enhance testosterone levels, all males were given also gonadotropin-releasing hormone agonist in order to block natural testosterone.
The results of the study manifested that fat-free mass was enhanced due to usage of testosterone. It didn’t differ substantially in males of these 2 groups. Muscle strength which was also enhanced due to intake of testosterone didn’t differ between the two groups too. Sexual activity, volume of prostate, sebum production, hemoglobin, acne, hematocrit didn’t differ essentially between those who administered placebo and dutasteride.
The specialists note that effectiveness of 5?-reductase inhibitors may be limited in men that have normal or increased levels of testosterone. That’s why it is necessary to measure testosterone levels in order to determine how bodies will respond to 5 ?-reductase inhibitors.
So, the study has demonstrated that muscle mass is not affected by 5?-reductase inhibitors. Men have to know that if they have enhanced levels of testosterone or introduce exogenous testosterone in their bodies, 5?-reductase inhibitors will not cause shrunken prostate.
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